ANALYSIS OF ATOPIC DERMATITIS AND ECZEMA RESISTANT FORMS ASSOCIATION WITH THE EXPRESSION OF XENOBIOTIC BIOTRANSFORMATION GENES IN THE SKIN OF PATIENTS

  • N. Milkoto State Educational Establishment “Belarusian Medical Academy of Postgraduate Education”
  • O. Pankratov “Belarusian Medical Academy of Postgraduate Education”
  • O. Poluyan “Belarusian Medical Academy of Postgraduate Education”
  • I. Shimanskaya “Belarusian Medical Academy of Postgraduate Education”
  • T. Rudenkova “Belarusian Medical Academy of Postgraduate Education”
  • S. Kostiuk “Belarusian Medical Academy of Postgraduate Education”
  • O. Pankratov “Belarusian Medical Academy of Postgraduate Education”
Keywords: atopic dermatitis, eczema, resistant forms, xenobiotic biotransformation genes, expression level

Abstract

As a result of the studies, a reliable association of the course of atopic dermatitis and eczema (resistant, often long-term relapsing, continuously-relapsing) with an increase in the expression levels of xenobiotic biotransformation genes (UGT1A7, HMOX2, BLVRA, CCL13, APOBR, ABCC2, GSTP1) in the skin was determined. The data obtained during the studies allow us to recommend the use of a method for assessing the expression levels of xenobiotic biotransformation genes in skin scrapings, based on real-time PCR, for early diagnosis and an objective choice of treatment tactics in patients suffering from resistant, often long-term, continuously-relapsing forms of atopic dermatitis and eczema.

References

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10. Rudenkova Tatyana Vladimirovna – Leading Researcher of the PCR Diagnostics Group of the Research Laboratory of the State Educational Establishment “Belarusian Medical Academy of
Postgraduate Education”, Candidate of Biological Sciences; Address: Minsk, 3 P. Brovki St., building 3. Tel.: 265-35-82. Kostiuk Svetlana Andreevna – Chief Researcher of the PCR Diagnostics Group of the Research Laboratory of the State Educational Establishment “Belarusian Medical Academy of Postgraduate Education”, Doctor of Medical Sciences, Professor; Address: Minsk, 3 P. Brovki St., building 3.
Tel.: 265-35-82. Shimanskaya Irina Grigorievna – Candidate of Medical Sciences; Associate Professor Pankratov Oleg Valentinovich – Head of the Department of Dermatovenereology and Cosmetology of the State Educational Establishment “Belarusian Medical Academy of Postgraduate Education”; Doctor of Medical Sciences, Professor; Address: Minsk, 3 P. Brovki St., building 3. Tel.: 372-74-40. Milkoto Nadezhda Alekseevna – Senior Lecturer of the Department of Dermatovenereology and Cosmetology of the State Educational Establishment “Belarusian Medical Academy of Postgraduate Education”; Address: Minsk, 3 P. Brovki St., building 3. Tel.: 222-89-12.
Published
2020-12-14
How to Cite
(1)
Milkoto , N.; Pankratov , O.; Poluyan , O.; Shimanskaya , I.; Rudenkova, T.; Kostiuk , S.; Pankratov , O. ANALYSIS OF ATOPIC DERMATITIS AND ECZEMA RESISTANT FORMS ASSOCIATION WITH THE EXPRESSION OF XENOBIOTIC BIOTRANSFORMATION GENES IN THE SKIN OF PATIENTS . Eurasian Union of Scientists 2020, 2, 29-35.

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