CATEPSIN B AS A POSSIBLE PREDICTOR OF GESTOSIS
Abstract
The issues of prevention and prediction of complications of pregnancy, determination of the tactics of diagnostic and therapeutic approaches in the management of gestation, childbirth, and the postpartum period, despite the progress made in this area of medicine, are far from being resolved.
In this article, a study is carried out on one of the sides of the problem of pathogenetic mechanisms of the development of gestosis. It was determined that this symptom complex develops mainly in the second half of pregnancy, against the background of various degrees of perinatal risk.
It was found that the activity of cathepsin B, a lysosomal enzyme of the hydrolase class, increases both in the control group during the physiological course of pregnancy and with an increase in gestational age, especially in patients with a burdened obstetric and gynecological history, somatic diseases, and other problems that arose during the prolongation of pregnancy ... We have found that the values of the parameters of this enzyme in the serum of the venous blood of pregnant women in the first, second and third trimesters of gestation are significantly higher in patients with already verified gestosis in the second half of pregnancy, compared with its normal development. It should be noted that the above changes manifest already at the beginning of gestation, that is, in its first trimester, which is not yet identified with the formation and development of a real symptom complex of gestosis, as well as other pathological influences on the state of the mother-placenta-fetus system.
References
Abalenikhina Yu.V., Fomina M.A., Matveeva I.V. Assessment of the state of lysosomal cysteine proteolysis of the spleen under conditions of modeling the deficiency of nitric oxide synthesis of different severity. "Biochemical scientific readings in memory of the academician of the RAS EA Stroev": materials of the All-Russian scientific and practical conference of students and young specialists with international participation. R., 2016, p. 183.
Borzova N.Yu., Gerasimov AM, Skripkina I.Yu., et al. The role of Cathepsin D in the pathogenesis of gestosis // Bulletin of new medical technologies. 2007.- T. XIV., No. 4 - P.75 ...
Gerasimov A.M., Borzova N.Yu., Kerimkulova N.V., Pavlov A.V. Cathepsin D - its physiological role and use in medicine: literature review // Clinical laboratory diagnostics: scientific and practical journal. - 2009.-№3.-С.3 - 5.
Dingle J. Research methods / Dingle J. - M .: Mir, 1980 .-- 344 p.
Pat. 2263913 Russia. Method for predicting preeclampsia / Borzova N.Yu. and others // BIPM, 2005, No. 11, p. 215.
Order of the Ministry of Health of the Russian Federation No. 572n dated 01.11.2012. "On approval of the Procedure for the provision of medical care in the profile of" obstetrics and gynecology "(except for the use of assisted reproductive technologies)";
Matveeva I.V. Cathepsin D: properties and functions / I.V. Matveeva // Actual problems of medical biochemistry: a collection of scientific papers based on the materials of the All-Russian scientific and practical conference “Biochemical scientific readings in memory of Academician E.A.Stroev ". - Ryazan., 2012.
Matveeva I.V., Marsyanova Yu.A. Physiological role of cathepsin D Materials of the All-Russian scientific-practical conference of students and young specialists from the international. participation February 4 - 6, 2016, Ryazan p.12-15.
Castino R., Pace D., Demoz M., Gargiulo M., Ariatta C., Raiteri R., Isidoro C. Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas // Int. J. Cancer. - 2002.–V. 97. - P. 9-12.
Nurmagomedova P.M., Sharbuzova P.A. Participation of cathepsin D in physiological and pathological processes of the body. Innovations in medicine and pharmacology: a collection of scientific papers based on the materials of the All-Russian scientific and practical conference of students and young professionals with international participation. M.,2018, p. 183. ...
Sidorova IS Late gestosis. M. 1996.236 p.
Sinitskaya NS The role of peptides in free radical oxidation and aging of the body / NS Sinitskaya, V. Kh. Khavinson // Success of sovr. biology. - 2002. - T. 122. - Issue. 6. - S. 557.
Udonova TA, Gavryuk SA, Bardinova Zh.S., et al. Activity of Cathepsin D in the placenta with preeclampsia of mild severity // Bulletin of the Penza State Pedagogical University. V.G.Belyaeva.-2008.-№2.-Pp. 219 - 221.
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